The Fire in the Genes

by Dr. Merrill Garnett The present day intellectual framework for the Biochemistry of cancer is based on the genetic code. Investigators have presumed that either the expression of oncogenes, or the failure of expression of tumor suppressor genes, is the basis of the disease. In practice however, present day chemotherapy has not benefited from this theory. And most of the pharmaceutical research has focused on interruption of the non-specific universal mechanisms of cell division. At the same time there is no gene-based explanation for the gradual maturation and aging of higher organisms. The genetic code, exquisite for explaining inheritance, does not give clear insight into the elegantly coordinated biochemical and structural changes occurring throughout the life of the organism. This dichotomy becomes more severe when we realize that the genetic code is the same for living and dead creatures. Therefore I have focused my research on the activation energies of the genome in order to delineate the differences between the living and dead states, and also between the maturing and the primitive states. Reports of Raman energy signatures in DNA is the first inkling that there is an intrinsic energy state which accompanies genetic material. These energy signatures have been shown to vary with the A and B oscillation configurations of DNA. This energy has also been shown to vary in subtle species-specific ways among the genes. For this reason, I have measured the electronic low frequency impedance oscillations of RNA and DNA and certain proteins. I have found and reported a number of wide-band oscillation frequencies within nucleic acids that demonstrate the storage of energy. I have also identified the specific electronic device identities of RNA and DNA and some immunoglobulins. To find the device identity of the biopolymers I used standard electronic impedance spectroscopic methods with a special background solution. This solution which I call a dielectrolyte, shields biological polymers from thermal and solvent current leakage. It allows current propagation as in an insulated wire or a coaxial line. Use of the dielectrolyte reveals that both DNA and RNA manifest magnetic inductance, and certain immunoglobulins are ideal capacitors. Together these biomolecules comprise a parallel resonant tank circuit which is a superb model for the biological pulse, and the energy variations in a wide variety of conditions. This data has supplied a model for the design of chemotherapy agents which manifest the normal resonant frequencies of RNA and DNA. The first of these compounds to be developed is the palladium-lipoic acid polymer known as palladium DNA reductase. This compound carries current from membrane fatty acids to DNA at the resonant frequencies of DNA. This current is disruptive to anaerobic cell systems including certain tumors. In the absence of oxygen, the strong polarization force of the current dissociates membrane proteins. This mechanism is studied by the use of oxygen-facultative Tetrahymena cells in both aerobic and anaerobic environments. Such mechanistic reactions allow clonal selection of competent aerobic cell systems from stem cells. This then serves as a model for maturation selection during the life of the organism, and a new direction in chemotherapy research.