Fight Four Signs of Aging with a Single Natural Substance

It’s hard to believe that a single substance could be responsible for diminishing the pain and deterioration of osteoarthritis… for giving your skin its smooth, elastic, youthful appearance…for being able to keep your eyes lubricated and protect them from damaging UV rays… and for supporting the health of the gums. But it’s true: One critical compound forms the backbone of all of these age-defying marvels. (1) Even better, this very substance occurs naturally as part of your own body’s most delicate and important cellular structures—at least, for a while. This substance is hyaluronic acid (HA)—and as a critical building-block of your body’s tissues and fluids, there’s no question that even modest shortages can add up to some serious problems for your daily health. The trouble is, your body’s levels of this health-sustaining molecule start to drop—and quickly—with advancing age. And the result is sagging skin, degenerating eyesight, expensive dental visits… and most notably, painful, aching, arthritic joints. Just because these changes are normal consequences of aging, that doesn’t mean you have to accept them. In fact, there’s absolutely no reason to—especially when HA supplementation has been proven in numerous clinical trials to be beneficial in reversing these distressing complications and more. Recent studies show that men and women over 40 with osteoarthritis in their knees reported a greater decrease in total symptoms and pain relief when supplementing with HA as opposed to placebo—while needing only half the anti-inflammatory pain medication—over a period of just eight weeks. (2) Similar results have been seen in older patients whose daily activities are limited by arthritis-related pain—with further clinical research demonstrating HA’s ability to reduce pain and inflammation, enhance DNA repair, and combat free radicals while protecting cartilage and increasing patient mobility. (3-6) These same abilities make HA a critical natural skin-saver—with applications that range from collagen regeneration to reducing most of the complications of disorders like oral lichen planus (OLP), a common inflammatory disease of the skin and mouth. (7-12)  And your vision can benefit, too—from the added protection HA offers against sun, eye strain, and dryness of the eyes. (13-16) Take HA’s natural antibacterial and tissue-healing properties into account—both of which support its role against gingivitis, periodontitis, canker sores, and other diseases of the mouth—and it’s hard to deny the usefulness of a quality HA supplement when it comes to averting the most common, painful annoyances of aging. (17-22) References: 1. Volpi N, Schiller J, Stern R, Soltés L. Role, metabolism, chemical modifications and applications of hyaluronan. Curr Med Chem. 2009;16(14):1718-1745. 2. Kalman DS, Heimer M, Valdeon A, Schwartz H, Sheldon E. Effect of a natural extract of chicken combs with a high content of hyaluronic acid (Hyal-Joint) on pain relief and quality of life in subjects with knee osteoarthritis: a pilot randomized double-blind placebo-controlled trial. Nutr J. 2008 Jan 21;7:3. 3. Strauss EJ, Hart JA, Miller MD, Altman RD, Rosen JE. Hyaluronic Acid Viscosupplementation and Osteoarthritis: Current Uses and Future Directions. Am J Sports Med. 2009 Feb 3. 4. Akmal M, Singh A, Anand A, et al. The effects of hyaluronic acid on articular chondrocytes. J Bone Joint Surg Br. 2005;87:1143-1149. 5. Grishko V, Xu M, Ho R, et al. Effects of hyaluronic acid on mitochondrial function and mitochondria-driven apoptosis following oxidative stress in human chondrocytes. J Biol Chem. 2009 Apr 3;284(14):9132-9139. 6. H, Nakamura H, Katayama K, et al. Effects of an oral administration of glucosamine-chondroitin-quercetin glucoside on the synovial fluid properties in patients with osteoarthritis and rheumatoid arthritis. Biosci Biotechnol Biochem. 2009 Feb;73(2):288-292. 7. Greco RM, Iocono JA, Ehrlich HP. Hyaluronic acid stimulates human fibroblast proliferation within a collagen matrix. J Cell Physiol. 1998 Dec;177(3):465-473. 8. Karna E, Miltyk W, Pałka JA, Jarzabek K, Wołczyński S. Hyaluronic acid counteracts interleukin-1-induced inhibition of collagen biosynthesis in cultured human chondrocytes. Pharmacol Res. 2006 Oct;54(4):275-281. 9. Nawrat P, Surazyński A, Karna E, Pałka JA. The effect of hyaluronic acid on interleukin-1-induced deregulation of collagen metabolism in cultured human skin fibroblasts. Pharmacol Res. 2005 May;51(5):473-477. 10. Pageon H, Bakala H, Monnier VM, Asselineau D. Collagen glycation triggers the formation of aged skin in vitro. Eur J Dermatol. 2007 Jan-Feb;17(1):12-20. 11. Tanaka M, Masuko-Hongo K, Kato T, Nishioka K, Nakamura H. Suppressive effects of hyaluronan on MMP-1 and RANTES production from chondrocytes. Rheumatol Int. 2006 Jan;26(3):185-190. 12 Nolan A, Badminton J, Maguire J, Seymour RA. The efficacy of topical hyaluronic acid in the management of oral lichen planus. J Oral Pathol Med. 2009 Mar;38(3):299-303. 13. Pauloin T, Dutot M, Joly F, Warnet JM, Rat P. High molecular weight hyaluronan decreases UVB-induced apoptosis and inflammation in human epithelial corneal cells. Mol Vis. 2009;15:577-583. 14. Johnson ME, Murphy PJ, Boulton M. Effectiveness of sodium hyaluronate eyedrops in the treatment of dry eye. Graefes Arch Clin Exp Ophthalmol. 2006 Jan;244(1):109-112. 15. Brignole F, Pisella PJ, Dupas B, Baeyens V, Baudouin C. Efficacy and safety of 0.18% sodium hyaluronate in patients with moderate dry eye syndrome and superficial keratitis. Graefes Arch Clin Exp Ophthalmol. 2005 Jun;243(6):531-538. 16. Acosta MC, Gallar J, Belmonte C. The influence of eye solutions on blinking and ocular comfort at rest and during work at video display terminals. Exp Eye Res. 1999 Jun;68(6):663-669. 17. Sukumar S, Drízhal I. Hyaluronic acid and periodontitis. Acta Medica (Hradec Kralove). 2007;50(4):225-228. 18. Pistorius A, Martin M, Willershausen B, Rockmann P. The clinical application of hyaluronic acid in gingivitis therapy. Quintessence Int. 2005 Jul-Aug;36(7-8):531-538. 19. Lee JH, Jung JY, Bang D. The efficacy of topical 0.2% hyaluronic acid gel on recurrent oral ulcers: comparison between recurrent aphthous ulcers and the oral ulcers of Behçet’s disease. J Eur Acad Dermatol Venereol. 2008 May;22(5):590-595. 20. Mendes RM, Silva GA, Lima MF, et al. Sodium hyaluronate accelerates the healing process in tooth sockets of rats. Arch Oral Biol. 2008 Dec;53(12):1155-1162. 21. Higuchi Y, Ansai T, Awano S, et al. Salivary levels of hyaluronic acid in female patients with dry mouth compared with age-matched controls: a pilot study. Biomed Res. 2009 Feb;30(1):63-68. 22. Yuan J, Tohara H, Mikushi S, Hoshino T, Yue B, Uematsu H. The effect of “Oral Wet” for elderly people with xerostomia—the effect of oral rinse containing hialuronan. Kokubyo Gakkai Zasshi. 2005 Mar;72(1):106-110. Article courtesy of Vitamin Research Products Health News.