Prescription drugs often become a necessary component of patients’ health. And that presents a new need — the need for physicians and pharmacists to discuss the possible ramifications of taking a prescription, including nutrient depletion in the body.

Most people are well-versed in the importance of vitamins, minerals, and herbs to their health. Stress, environmental pollutants, and poor diet all contribute to the depletion of nutrient levels in the body. Unfortunately, most people are not aware of how prescription drugs create drug-induced nutrient depletion. This is an important issue that becomes even more important when a patient must take a prescription for a chronic condition.

As America ages, it’s inevitable that more of the population will need prescription drugs for chronic conditions. There’s already an influx of prescriptions for Americans’ high blood pressure, high cholesterol levels, heart disease, and other health concerns. This is a prime opportunity to educate your patients about the need for nutritional therapy as an adjunct to taking prescription medications. Not only does this benefit the patient, but also enables you to integrate natural medicines into your clinic or pharmacy.

Consider that anti-hypertensive medications for blood pressure, drugs that comprise the sixth largest dollar-volume category of prescription drugs in the U.S. in 1998, will deplete zinc in the body. This mineral is crucial to the immune system and its many functions including wound healing and infection fighting. A zinc deficiency can also cause insulin resistance and sexual dysfunction.

Cholesterol-lowering drugs such as LipitorR and ZocorR comprise the third largest category of prescription drugs in the United States in 1998 and can easily deplete Coenzyme Q10(CoQ10). On the flip side, magnesium may inhibit the absorption of these drugs. And even commonplace NSAIDs deplete nutrients like folic acid And it’s this deficiency that poses greater risk for women because of the link to cervical dysplasia and birth defects in their children. Other problems associated with a lack of adequate folic acid include anemia, depression, elevated homocysteine levels (and corresponding risk of cardiovascular disease), and increased risks for developing breast and colorectal cancers.

Natural Medicine Online offers a chart of the most commonly prescribed drugs and their corresponding effects on body nutrient levels. Please use this chart to educate yourself about the added importance of nutritional supplements and natural medicines when taking prescription medications.

Top Prescription Drugs

NorvascR, ProcardiaR, and AdalatR
Description: Types of anti-anginal drugs used for heart disease. 
Depletion: Procardia and Adalat can cause potassium depletion (hypokalemia)
Interactions: Ingestion of grapefruit or grapefruit juice has been shown to increase the blood levels of these drugs and may increase side effects.
Nutritional Support: Krebs Magnesium- Potassium Chelates.
 
NSAIDS including AleveR, aspirin, ibuprofen, FeldeneR, IndocinR, RelafenR, NaprelanR, Naprosyn, etc.
Description: Types of anti-inflammatory drugs.
Depletion: Iron, folic acid, zinc, vitamin C, and possibly vitamin B12.
Interactions: High dosages of vitamin E (i.e.,>400 IU/day) can decrease platelet aggregation. This may result in additive blood thinning effects already present in NSAIDs.
Nutritional Support: Glucosamine Sulfate, a high potency daily multiple vitamin for women or men, and MSM.

PremarinR, PremproR, and other estrogen hormones
Description: Types of estrogen replacement (HRT) used for menopause. 
Depletion: Vitamin B6, folic acid, niacin, and vitamin C. 
Interactions: Red clover extracts and soy isoflavones may interfere with absorption.Vitamin D, calcium, zinc, magnesium, and ipriflavone may increase absorption.
Nutritional Support: A high potency daily mutiple vitamin for women or women 45+ and standardized black cohosh. Standardized black cohosh is effective for relief of menopause symptoms.

PrilosecR and other proton pump inhibitors
Description: Types of ulcer/gastric reflux medications (GERD)
Depletion: Vitamin B12.
Interactions: May decrease the absorption of calcium, magnesium, and other minerals by blocking the release of stomach acid.
Nutritional Support: Vitamin B12(Methylcobalamin) and a high potency daily multiple vitamin for women or men. Gastro-ReliefT helps relieve acid indigestion.

ProzacR, ZoloftR, and other SSRIs
Description: Types of anti-depressants. 
Depletion: Melatonin.
Interactions: Low levels of B vitamins may reduce the effectiveness of these drugs.
Nutritional Support: St. John’s Wort and 5-HTP should not be taken with any SSRI unless under a physician’s supervision. Melatonin and a complete daily multiple vitamin for women or men.

SynthroidR and other thyroid hormone medications (EltroxinR, Levo-TR, LevothroidR, LevoxylR, EuthroidR, ThyrolarR, etc.)
Description: Types of thyroid hormone replacement.
Depletion: Calcium. 
Interactions: Iron supplements and soy products taken at the same time as SynthroidR may interfere with absorption.
Nutritional Support: Milk thistle extract standardized to contain 70% silymarin. Thyroid preparations are best taken on an empty stomach at the same time every day.

VasotecR, CapotenR, (Captopril), PrinivilR, ZestrilR
Description: Types of (anti-hypertensives) medications for blood pressure.
Depletion: Zinc.
Interactions: These drugs may increase blood levels of potassium above normal or reduce potassium excretion in urine.
Nutritional Support: A high potency daily multiple vitamin for women or men.

Albuterol (ProventilR, VentolinR)
Description: Types of bronchodilator (asthma).
Depletion: Magnesium and calcium.
Nutritional Support: A high potency daily multiple vitamin for men or women and Krebs Magnesium-Potassium Chelates. BronchorilT can help keep airways free of mucus.

Amoxicillin preparations including AugmentinR, AmoxilR, PolymoxR, TrimoxR, and others
Description: Types of antibiotics.
Depletion: Biotin, vitamin K, and possibly other B vitamins.
Interaction: The enzyme bromelain increases the absorption of amoxicillin and other antibiotics.
Nutritional Support: Acidophilus and bromelain. Lactobacillus acidophilus preparations can be taken with antibiotics. 

ClaritinR, ClaritinR-D
Description: Types of allergy medications.
Depletion: None known
Interactions: None known
Nutritional Support: A high potency daily multiple vitamin for women or men.

CoumadinR (warfarin)
Description: Types of anticoagulant therapy used for heart disease (blood thinner).
Depletion: None known.
Interactions: Vitamin K may decrease the effect of CoumadinR.
Nutritional Support: Ginkgo biloba extract, vitamin E, and aspirin may increase the effect of Coumadin. A high potency, standardized grape seed extract helps to maintain healthy blood vessels. Iron, magnesium, and zinc may bind with CoumadinR and decrease its absorption. Take any supplement containing these compounds at least two hours before or after taking CoumadinR. 

Diuretics including LasixR, AldactoneR, EsidrixR, HydrodiurilR, EdecrinR
Description: Types of blood pressure medications also used for fluid retention.
Depletion: Potassium, magnesium, and B vitamins (especially thiamin). 
Interactions: Diuretics cause the body to excrete higher levels of potassium, magnesium, and B vitamins. However, calcium levels tend to be preserved.
Nutritional Support: A high potency daily multiple vitamins for women or men. Potassium supplementation is routinely provided by medical doctors when they prescribe diuretics

GlucophageR, also DiaBetaR, MicronaseR, GlucotrolR
Description: Types of oral anti-diabetic agents.
Depletion: Folic acid and vitamin B12. 
Interactions: These drugs should be taken on an empty stomach.
Nutritional Support: Magnesium, chromium, and a high potency daily multiple for diabetics. Diabetics have higher needs for virtually all nutrients, especially vitamins C, E, and B, magnesium, and chromium. 

LanoxinR (digoxin) 
Description: Type of inotropic heart medication.
Depletion: Magnesium, potassium, and thiamine.
Interactions: Low levels of potassium increase the risk of digoxin toxicity. Siberian ginseng should not be used with Lanoxin.
Nutritional Support: Krebs Magnesium-Potassium Chelates, and high potency daily multiple vitamin for women or men. Avoid licorice extract unless it is deglycyrrhizinated.

LipitorR, MevacorR, ZocorR, PravacholR, and other HMG CoA Reductase Inhibitors.
Description: Types of anti-cholesterol medications.
Depletion: Coenzyme Q10.
Interactions: Magnesium may inhibit the absorption of these drugs. High doses of niacin will increase risk for adverse liver effects and myopathies.
Nutritional Support: Coenzyme Q10 (softgel). Do not use concomitantly with red yeast rice products unless under the supervision of a physician.

Editor’s Note: Medical science has known for decades that even the most wonderful drugs of our time have a certain time and place for use. LONG TERM USE OF ANY DRUG HARMS THE BODY IN SOME WAY, SHAPE OR FORM. That is not to discount that some medications are keeping people healthy, rater that there is damaging being done elsewhere. The recent explosion of the pharmaceutical companies wanting people to stay on medication for the long term is primarily financially-driven. Our medical system is designed not around developing good health through good habits but what magic pill can we take to fix our problem. We all know what type of situations this short-term thinking can mean for our long-term health. It only hurts our health! The good news is that more research and more people are changing their lives through proper nutrition, exercise and supplementation. The top 4 supplements that are showing a great synergistic effect are CoQ10, Vitamin D, Fish Oils, and POLY-MVA.  The most exciting of these supplements is POLY-MVA. It’s a revolutionary, complexed supplement which can protect our cells and provide cellular energy support at the same time. The combination of these supplements not only protects and supports our cells but work across the basic fundamentals of good health and for many different situations - diabetic patients, stroke, cardiac situations and cancer cases, to name a few. By specifically targeting metabolic therapy, protection and support you really give your body the best chance of being healthy.

by Christopher Wanjek (LiveScience’s Bad Medicine Columnist)

Scientists are now reporting a breakthrough therapy to lower the risk of developing the most common and deadly chronic diseases - diabetes, cardiovascular disease and cancer - by about 80 percent.

In some ways, this might sound like old news. The therapy is called taking care of yourself: not smoking, exercising regularly, eating a healthy diet and maintaining a healthy weight.

True, you’d have to be smoking something hallucinogenic to not understand that cigarettes are unhealthy. Take away cigarettes, and you take away lung cancer and a good deal of heart disease. Similarly, the mantra of eating right and exercising has been drilled into us. Pork rinds and videogame expertise does not a healthy body make.

What’s new, though, is evidence of the cumulative protective effect provided by all four healthy factors. The research, published in a recent issue of the Archives of Internal Medicine, involves over 23,000 Germans and is part of a larger, ongoing European study on lifestyle choices and disease.

Action cheaper than reaction

Americans, an ever ingenious and resourceful lot, are now debating how to have a world-class healthcare system without paying for it through higher taxes or taking steps to improve their health. Maybe we’ll succeed; we’ve defied gravity before. But this radical idea of taking care of yourself could help.

Chronic diseases are expensive because, as the name implies, they stay around usually for the rest of your life. This adds up in terms of drug costs, surgery, hospital stays, missed work and lower productivity.

Obesity is costing the American healthcare system more than $100 million annually. And while there’s some overlap, diabetes costs nearly $150 billion, cancer care costs more than $200 billion, and heart disease costs more than $300 billion annually, according to studies by the National Institutes of Health.

The way it was

Cancer is difficult to cure simply with lifestyle changes. Lung cancer would go away, but the four aforementioned health factors contributed to “only” a 36-percent reduced risk of all cancers on average.

Diabetes, on the other hand, doesn’t need to exist. And it hardly did exist until the 20th century. The researchers found that four health factors contributed to a 93-percent reduced risk in developing diabetes among the people in the study.

Heart disease, too, is largely preventable. Here the risk of a heart attack was lowered by 81 percent. In fact an unrelated study, also published this week, in PLoS ONE, suggests that heart attacks and strokes may have been rare for the vast majority of human history.

For this PLoS One study, team led by Michael Gurven of University of California, Santa Barbara, studied a remote Amazonian tribe in Bolivia known as the Tsimane. They found that peripheral arterial disease does not increase with age in this population despite risk factors found in industrialize countries, such as chronic inflammation and tobacco use. The implication is that these risk factors become deadly only in the context of an unhealthy diet and an inactive lifestyle.

Of course, life isn’t a paradise in the Amazon. Life expectancy is around 50 years, and half the Tsimane die from infectious or parasitic disease. Other leading causes of death are accidents and violence. Yet they remain mostly remarkably fit throughout life. This is the natural state for humans.

Genetic connection

Genetics do play some role in chronic disease.

For example, some people pack on extra pounds easily. Yet as the German study and other large studies are revealing, the obesity epidemic is mostly driven by lifestyle choices. The genetic predisposition, if any, is not the ease in gaining weight but the difficulty in losing it.

And so…

More certain is American’s genetic predisposition to rely on liposuction, stomach stapling, angioplasty, bypass surgery, dialysis and lots and lots of prescription drugs to fight disease. But the key to affordable healthcare, according to these two studies, is to pay for disease prevention, not treatment - and, perhaps, to avoid poisonous blow darts.
Christopher Wanjek is the author of the books “Bad Medicine” and “Food At Work.” His column, Bad Medicine, appears each Tuesday on LiveScience.

Poor eating habits precipitate more than just an enlarging waistline. They affect every aspect of your health, and although you may not notice it right away, your hormone levels suffer dramatically from sugary, fatty, and nutritionally-deficient foods. Many of your beneficial hormones will nose-dive, while the other more dangerous hormones - like insulin - skyrocket.

Insulin Resistance Syndrome

Our bodies do need sugar (glucose) as a fuel for our cells to perform their daily cellular functions. When we eat sugar or foods that are broken down into glucose such as high-glycemic carbohydrates, our body’s digestive process puts that glucose into the blood stream for the cells to collect and utilize. The cells rely on the pancreas to monitor the blood levels and to alert them when glucose is abundant. The pancreas does this by secreting insulin which circulates through our bodies delivering the message to the cells of glucose’s presence.

In perfect balance, when we eat carbohydrates and produce glucose, the cells use it up as energy and there is little left over.

When our cells ignore insulin and become resistant

Over the course of years as we get older, become more sedentary, and our diets become “sugar loaded,” we process more glucose than our cells can use and the excess floats around in our blood, or is turned into fat in the cells.

Insulin Resistance also increases the symptoms and/or risk factors associated with metabolic syndrome, contributing to:

1. Accumulation of body fat
2. Obesity
3. Elevated triglycerides
4. High blood pressure.
5. Acceleration of the aging process.

Diet

It is commonly accepted that eating large amounts of simple carbohydrates (pastas, breads, and sugar filled foods) could lead to Insulin Resistance, elevated cholesterol, elevated triglycerides, and obesity. For this reason, as part of our program, we recommend that our patients change to a low-glycemic index diet.

The Glycemic Index is the rate that carbohydrates break down into sugar in the blood. The best source of low-glycemic carbohydrates are vegetables. Vegetables are slow burning carbohydrates and help keep insulin levels steady.

A diet rich in vegetables, proteins, good fats in the form of omega-3, and water is optimal for a long health span.

It is important to point out that a single diet will not work for everyone. To optimize your nutritional needs you should visit with an experienced health care professional well versed in the issues of metabolic syndrome and nutrition.

Editor’s Note: Targeting cellular health and energy support is key to helping your body regulate its hormones and get the most benefit from a healthy diet. A key supplement in metabolic support, cellular energy production and protection is POLY-MVA. Its unique complex of alpha lipoic acid, B-1 and the mineral palladium make it ideal for these types of situtiaons. Only ¼-1/2 tsp per day and you have the added benefit of a superior antioxidant while at the same time supporting energy production for you cells. Read more…

by Sarah Baldauf

Added sugars, which are sprinkled on and processed into packaged foods and beverages, have become all too common in the American diet, says the American Heart Association. The group argues that sugar bingeing is helping drive the uptick in metabolic changes in the American population, including the exploding obesity rate, and has now recommended an upper limit on daily consumption. (Sugar intake and cancer: What’s the link?) Women should consume no more than 100 calories per day of added sugars, and men should not top 150 calories per day. There goes the soda habit: One 12-ounce can contains about 8 teaspoons or about 33 grams of added sugar, which equals approximately 130 calories, notes the AHA. One gram of sugar serves up 4 calories, according to the American Dietetic Association.

With math like that, it’s not surprising that the average American rings up an average of 22.2 teaspoons, or 355 calories per day, of added sugars, mostly from sugar-sweetened beverages. But those who shun sweet-tasting drinks are not off the hook. Part of the challenge of avoiding added sugars, argues the AHA, is that they have become far more prevalent over time; the amount of added sugars in Americans’ food options increased 19 percent between 1970 and 2005.

Here are 11 sneaky dietary sources that are surprisingly high in added sugars based on serving sizes from non-brand name nutrition labels at www.nutritiondata.com. The per-serving figures allow you to calculate your own added sugar intake, both in grams and calories, if you use more or less.

1. Fortune cookies. Just one fortune cookie packs about 3.6 grams of added sugar.

2. Flavored booze. Exercise good judgment when you drink: One ounce of crème de menthe has 14 grams of added sugar; 53-proof coffee-flavored liqueur has 16 grams of added sugar per ounce.

3. Baked beans. A one-cup serving of canned baked beans with no salt added will cost you nearly 15 grams of added sugar.

4. Dried, sweetened cranberries. Without the sweetener, this fruit can be incredibly tart. But one serving-a third of a cup-of this treat will hit you with 25 grams of added sugar.

5. Ketchup. A favorite condiment, a single one-cup serving of regular-or low sodium-ketchup racks up nearly 40 grams of added sugar.

6. Cream substitutes. A one-cup serving of a liquid “light” cream substitute packs 22 grams of added sugar, while a one-cup serving of a powdered “light” cream substitute adds a whopping 69 grams.

7. BBQ sauce. A one-cup serving of this summertime favorite adds 9 grams of added sugar onto those ribs and chicken.

8. “Reduced” salad dressings. A one-cup serving of reduced-calorie French dressing heaps 58 grams of added sugar, and a one-cup serving of reduced-fat coleslaw dressing hits a home run with 103 grams of added sugar.

9. Lemonade. A cup of lemonade powder has a massive 200 grams of added sugar. A single serving of the drink has almost 17 grams of added sugar.

10. Flavored popcorn. Think the added sweetener can’t be that bad here? Fat-free-syrup caramel popcorn has 18 grams of added sugar per ounce serving.

11. Granola bars. Often deemed a healthful snack, some are tricky-a 1-ounce serving of a granola bar with oats, fruit, and nuts has 11 grams of added sugar.

Source: http://health.yahoo.com/featured/35/foods-surprisingly-high-in-added-sugar/

It’s hard to believe that a single substance could be responsible for diminishing the pain and deterioration of osteoarthritis… for giving your skin its smooth, elastic, youthful appearance…for being able to keep your eyes lubricated and protect them from damaging UV rays… and for supporting the health of the gums.

But it’s true: One critical compound forms the backbone of all of these age-defying marvels. (1) Even better, this very substance occurs naturally as part of your own body’s most delicate and important cellular structures—at least, for a while.

This substance is hyaluronic acid (HA)—and as a critical building-block of your body’s tissues and fluids, there’s no question that even modest shortages can add up to some serious problems for your daily health. The trouble is, your body’s levels of this health-sustaining molecule start to drop—and quickly—with advancing age. And the result is sagging skin, degenerating eyesight, expensive dental visits… and most notably, painful, aching, arthritic joints.

Just because these changes are normal consequences of aging, that doesn’t mean you have to accept them. In fact, there’s absolutely no reason to—especially when HA supplementation has been proven in numerous clinical trials to be beneficial in reversing these distressing complications and more.

Recent studies show that men and women over 40 with osteoarthritis in their knees reported a greater decrease in total symptoms and pain relief when supplementing with HA as opposed to placebo—while needing only half the anti-inflammatory pain medication—over a period of just eight weeks. (2) Similar results have been seen in older patients whose daily activities are limited by arthritis-related pain—with further clinical research demonstrating HA’s ability to reduce pain and inflammation, enhance DNA repair, and combat free radicals while protecting cartilage and increasing patient mobility. (3-6)

These same abilities make HA a critical natural skin-saver—with applications that range from collagen regeneration to reducing most of the complications of disorders like oral lichen planus (OLP), a common inflammatory disease of the skin and mouth. (7-12)  And your vision can benefit, too—from the added protection HA offers against sun, eye strain, and dryness of the eyes. (13-16)

Take HA’s natural antibacterial and tissue-healing properties into account—both of which support its role against gingivitis, periodontitis, canker sores, and other diseases of the mouth—and it’s hard to deny the usefulness of a quality HA supplement when it comes to averting the most common, painful annoyances of aging. (17-22)

References:
1. Volpi N, Schiller J, Stern R, Soltés L. Role, metabolism, chemical modifications and applications of hyaluronan. Curr Med Chem. 2009;16(14):1718-1745.
2. Kalman DS, Heimer M, Valdeon A, Schwartz H, Sheldon E. Effect of a natural extract of chicken combs with a high content of hyaluronic acid (Hyal-Joint) on pain relief and quality of life in subjects with knee osteoarthritis: a pilot randomized double-blind placebo-controlled trial. Nutr J. 2008 Jan 21;7:3.
3. Strauss EJ, Hart JA, Miller MD, Altman RD, Rosen JE. Hyaluronic Acid Viscosupplementation and Osteoarthritis: Current Uses and Future Directions. Am J Sports Med. 2009 Feb 3.
4. Akmal M, Singh A, Anand A, et al. The effects of hyaluronic acid on articular chondrocytes. J Bone Joint Surg Br. 2005;87:1143-1149.
5. Grishko V, Xu M, Ho R, et al. Effects of hyaluronic acid on mitochondrial function and mitochondria-driven apoptosis following oxidative stress in human chondrocytes. J Biol Chem. 2009 Apr 3;284(14):9132-9139.
6. H, Nakamura H, Katayama K, et al. Effects of an oral administration of glucosamine-chondroitin-quercetin glucoside on the synovial fluid properties in patients with osteoarthritis and rheumatoid arthritis. Biosci Biotechnol Biochem. 2009 Feb;73(2):288-292.
7. Greco RM, Iocono JA, Ehrlich HP. Hyaluronic acid stimulates human fibroblast proliferation within a collagen matrix. J Cell Physiol. 1998 Dec;177(3):465-473.
8. Karna E, Miltyk W, Pałka JA, Jarzabek K, Wołczyński S. Hyaluronic acid counteracts interleukin-1-induced inhibition of collagen biosynthesis in cultured human chondrocytes. Pharmacol Res. 2006 Oct;54(4):275-281.
9. Nawrat P, Surazyński A, Karna E, Pałka JA. The effect of hyaluronic acid on interleukin-1-induced deregulation of collagen metabolism in cultured human skin fibroblasts. Pharmacol Res. 2005 May;51(5):473-477.
10. Pageon H, Bakala H, Monnier VM, Asselineau D. Collagen glycation triggers the formation of aged skin in vitro. Eur J Dermatol. 2007 Jan-Feb;17(1):12-20.
11. Tanaka M, Masuko-Hongo K, Kato T, Nishioka K, Nakamura H. Suppressive effects of hyaluronan on MMP-1 and RANTES production from chondrocytes. Rheumatol Int. 2006 Jan;26(3):185-190.
12 Nolan A, Badminton J, Maguire J, Seymour RA. The efficacy of topical hyaluronic acid in the management of oral lichen planus. J Oral Pathol Med. 2009 Mar;38(3):299-303.
13. Pauloin T, Dutot M, Joly F, Warnet JM, Rat P. High molecular weight hyaluronan decreases UVB-induced apoptosis and inflammation in human epithelial corneal cells. Mol Vis. 2009;15:577-583.
14. Johnson ME, Murphy PJ, Boulton M. Effectiveness of sodium hyaluronate eyedrops in the treatment of dry eye. Graefes Arch Clin Exp Ophthalmol. 2006 Jan;244(1):109-112.
15. Brignole F, Pisella PJ, Dupas B, Baeyens V, Baudouin C. Efficacy and safety of 0.18% sodium hyaluronate in patients with moderate dry eye syndrome and superficial keratitis. Graefes Arch Clin Exp Ophthalmol. 2005 Jun;243(6):531-538.
16. Acosta MC, Gallar J, Belmonte C. The influence of eye solutions on blinking and ocular comfort at rest and during work at video display terminals. Exp Eye Res. 1999 Jun;68(6):663-669.
17. Sukumar S, Drízhal I. Hyaluronic acid and periodontitis. Acta Medica (Hradec Kralove). 2007;50(4):225-228.
18. Pistorius A, Martin M, Willershausen B, Rockmann P. The clinical application of hyaluronic acid in gingivitis therapy. Quintessence Int. 2005 Jul-Aug;36(7-8):531-538.
19. Lee JH, Jung JY, Bang D. The efficacy of topical 0.2% hyaluronic acid gel on recurrent oral ulcers: comparison between recurrent aphthous ulcers and the oral ulcers of Behçet’s disease. J Eur Acad Dermatol Venereol. 2008 May;22(5):590-595.
20. Mendes RM, Silva GA, Lima MF, et al. Sodium hyaluronate accelerates the healing process in tooth sockets of rats. Arch Oral Biol. 2008 Dec;53(12):1155-1162.
21. Higuchi Y, Ansai T, Awano S, et al. Salivary levels of hyaluronic acid in female patients with dry mouth compared with age-matched controls: a pilot study. Biomed Res. 2009 Feb;30(1):63-68.
22. Yuan J, Tohara H, Mikushi S, Hoshino T, Yue B, Uematsu H. The effect of “Oral Wet” for elderly people with xerostomia—the effect of oral rinse containing hialuronan. Kokubyo Gakkai Zasshi. 2005 Mar;72(1):106-110.

Article courtesy of Vitamin Research Products Health News.